Surface stabilized atorvastatin nanocrystals with improved bioavailability, safety and antihyperlipidemic potential

Systematic Development of Self-Emulsifying Drug Delivery Systems of Atorvastatin with Improved Bioavailability Potential

The aim of this study was to prepare and characterize a self-emulsifying drug delivery system (SEDDS) with a high drug load of poorly water-soluble atorvastatin for the enhancement of dissolution and oral bioavailability. Solubility of atorvastatin in oil, surfactant, and cosurfactant was determined. Pseudo-ternary phase diagrams were constructed by the aqueous titration method, and formulation...

Optimized zein nanospheres for improved oral bioavailability of atorvastatin

BACKGROUND This work focuses on the development of atorvastatin utilizing zein, a natural, safe, and biocompatible polymer, as a nanosized formulation in order to overcome the poor oral bioavailability (12%) of the drug. METHODS Twelve experimental runs of atorvastatin-zein nanosphere formula were formulated by a liquid-liquid phase separation method according to custom fractional factorial d...

Luminescence Properties of Thiol-Stabilized CdTe Nanocrystals

Thiol-capped CdTe nanocrystals with cubic zinc blende structure are synthesized in aqueous solution. Their steady-state and time-resolved luminescence characteristics are studied at room and liquid nitrogen temperatures. A strong exciton luminescence peak at 2.3 eV dominates the emission spectrum of CdTe nanocrystals at room temperature, whereas the trap band centered at 2.0 eV undergoes substa...

Electrospun Silk Fibroin Nanofibers with Improved Surface Texture

Novel Curcumin Intravenous Injection System: Preparation, Characterization, Improved Bioavailability and Safety In Vitro and In Vivo

Curcumin (CUR), a naturally bioactive component in the Curcuma longa have a wide range of biological and pharmacological actions. However, the poor water solubility with poor bioavailability limits its application. The aim of this study was to develop a novel CUR intravenous injection to improve CUR absorption and enhance drug therapy effect. The physical characteristics of CUR intravenous inje...